Poppers and other drugs
 

I know its strongly reccommended not to take poppers and viagra together but is there any other drugs that shouldnt be mixed with poppers?I am not sure about things like Cialis

Cialis and Viagra are brand names for the same drug. Both will lower your blood pressure so both are bad are to mix with poppers which also work by artificially lowering your blood pressure.

Any other drugs that lower your blood pressure would be bad for the same reasons.

That's not actually correct.

Cialis is Tadalafil. Viagra is Sildenafil.

Chemically Tadafil is 6R-trans)-6-(1,3-benzodioxol-5-yl)- 2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1', 2':1,6] pyrido[3,4-b]indole-1,4-dione.

Chemically Sildenafil is 1-[4-ethoxy-3-(6,7-dihydro-1-methyl-
7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)
phenylsulfonyl]-4-methylpiperazine.

These are actually very different molecules. However, they are both phosphodiesterase type 5 inhibitors so cause temporary hypotension so are not appropriate to take with poppers as far as I am aware.

I suggest looking on medical websites for advice on poppers by looking under the name of the substances typically used in them, which can be found on Wikipedia.

So that looks like any pills that help with an erection .Is that because they are made of chemicals,what about herbal ones?

Everything from the atomic level upwards is made of 'chemicals', from the chemical elements such as sodium or hydrogen, up to molecules like water and on upwards to everything around us. We might not think of them as chemcials. But they are. So, it is not to do with whether these are 'chemicals' or not.

The drugs for erectile disfunction are what are known as phosphodiesterase type 5 inhibitors (PDE5 inhibitors) so they all function in essentially the same way, but may have different efficacy and side effects.

The 'herbal' products are also chemicals (a whole variety of them), but will not have been through clinical trials for their effectiveness and safety. They may also be variable in their quality as the herb, tree, root etc they are made from will have natural variations in its composition. The manufacture of these products will almost certainly not be subject to the same level of scrutiny (quality control etc) as the properly authorised PDE5 inhibitors.

Those of us with long memories may remember the old adverts for substances such as 'Spanish Fly', 'Horny Goat Weed' etc etc. People have always wanted substances to enhance the erection or stoke the libido. If any of these truly worked without problems then we would all know about them and the PDE5 inhibitors would never have found the huge market that they have.

God knows I'm the last person to criticise anyone for splitting hairs but differentiating at a molecular level seems perhaps just a teensy tiny bit over zealous.

At a practical level Lady Anna was right-the effect is identical and the contra indication is the same for both

It's because they lower your blood pressure. Poppers also lowers your blood pressure. When your blood pressure lowers your heart automatically beats faster to ensure, your body assumes you are standing, that your blood, which carries oxygen, reaches your brain, hence why you flush around the neck and face, feel hot and get a high from all the extra O2 and endorphins.

So poppers relax and thus enlarge veins, which lowers blood pressure, which makes heart beat faster, which increases blood circulation, which sends more blood to head, to protect brain.

Add Viagra, or Cialis or similar and you can cause an overload resulting in possible coma. Or heart attack. Or both.

I very much doubt that herbal would have the same effect.

Thanks for that clear explaination

No.

In terms of drugs if something is a different molecule it is a different drug. As simple as that. It is not splitting hairs.

Added to which, their effect is not identical. Cialis is known for lasting longer, in terms of helping achieve an erection longer after it has been taken than Viagra. Viagra is cited as having a possibility of causing blurred vision.

Am I saying they are totally different in what they do or potential side effects etc? Of course not. But when it comes to drugs we should not say drugs are the same when they are not because even a small difference can be important to people with particular medical conditions. A mistake was made and I just clarified the actual situation - that's all.

Sorry to be a fuss pot again (as this is what at least one person thinks I am being) over this thread, but there are some important things to appreciate here........

The problem is that 'herbal' products can be almost anything. What your purchase says on the packet may not be what's in the pill.

Some products marketed as 'herbal' viagras may contain other PDE5 inhibitors and so may have the a similar effect and risks as the others that are properly authorised medicines.

If you don't believe me you can find an example here....

http://thechart.blogs.cnn.com/2010/1...ncement-pills/

So, to the OP, don't take 'herbal' products that purport to be for ED in conjunction with poppers either.