Poppers and other drugs

[londonsub]

So that looks like any pills that help with an erection .Is that because they are made of chemicals,what about herbal ones?

[MrBromley]

Everything from the atomic level upwards is made of 'chemicals', from the chemical elements such as sodium or hydrogen, up to molecules like water and on upwards to everything around us. We might not think of them as chemcials. But they are. So, it is not to do with whether these are 'chemicals' or not.

The drugs for erectile disfunction are what are known as phosphodiesterase type 5 inhibitors (PDE5 inhibitors) so they all function in essentially the same way, but may have different efficacy and side effects.

The 'herbal' products are also chemicals (a whole variety of them), but will not have been through clinical trials for their effectiveness and safety. They may also be variable in their quality as the herb, tree, root etc they are made from will have natural variations in its composition. The manufacture of these products will almost certainly not be subject to the same level of scrutiny (quality control etc) as the properly authorised PDE5 inhibitors.

Those of us with long memories may remember the old adverts for substances such as 'Spanish Fly', 'Horny Goat Weed' etc etc. People have always wanted substances to enhance the erection or stoke the libido. If any of these truly worked without problems then we would all know about them and the PDE5 inhibitors would never have found the huge market that they have.

[Lady Anna]

Originally Posted by londonsub

So that looks like any pills that help with an erection .Is that because they are made of chemicals,what about herbal ones?

It's because they lower your blood pressure. Poppers also lowers your blood pressure. When your blood pressure lowers your heart automatically beats faster to ensure, your body assumes you are standing, that your blood, which carries oxygen, reaches your brain, hence why you flush around the neck and face, feel hot and get a high from all the extra O2 and endorphins.

So poppers relax and thus enlarge veins, which lowers blood pressure, which makes heart beat faster, which increases blood circulation, which sends more blood to head, to protect brain.

Add Viagra, or Cialis or similar and you can cause an overload resulting in possible coma. Or heart attack. Or both.

I very much doubt that herbal would have the same effect.

[londonsub]

Originally Posted by Lady Anna

It's because they lower your blood pressure. Poppers also lowers your blood pressure. When your blood pressure lowers your heart automatically beats faster to ensure, your body assumes you are standing, that your blood, which carries oxygen, reaches your brain, hence why you flush around the neck and face, feel hot and get a high from all the extra O2 and endorphins.

So poppers relax and thus enlarge veins, which lowers blood pressure, which makes heart beat faster, which increases blood circulation, which sends more blood to head, to protect brain.

Add Viagra, or Cialis or similar and you can cause an overload resulting in possible coma. Or heart attack. Or both.

I very much doubt that herbal would have the same effect.

Thanks for that clear explaination

[MrBromley]

Originally Posted by Lady Anna

I very much doubt that herbal would have the same effect.

Sorry to be a fuss pot again (as this is what at least one person thinks I am being) over this thread, but there are some important things to appreciate here........

The problem is that 'herbal' products can be almost anything. What your purchase says on the packet may not be what's in the pill.

Some products marketed as 'herbal' viagras may contain other PDE5 inhibitors and so may have the a similar effect and risks as the others that are properly authorised medicines.

If you don't believe me you can find an example here....

http://thechart.blogs.cnn.com/2010/1...ncement-pills/

So, to the OP, don't take 'herbal' products that purport to be for ED in conjunction with poppers either.

[Lady Anna]

Mistresses usually advise no Viagra, no Cialis, or similar.

[ex nihilo]

It’s well documented that any form of organic nitrate or NO* donor is contraindicated in use with Viagra, Levitra and Cialis (PDE-5 inhibitors).

Post marketing severe adverse events safety data passed to regulatory authorities shows that PDE-5 inhibitors and nitrates interact to reduce blood flow in arteries with signs of narrowing, causing a major drop in blood pressure (drops of 40mm Hg are often seen). This depletes the heart of oxygen. The oxygen deprived heart will further decrease blood pressure and the downward spiral continues sometimes with catastrophic results. The effects would be more exaggerated if the person already has low BP or is taking antihypertensive drugs.

*NO is nitric oxide which can be synthesised in the body from amino acids and plays a role in the signalling of muscle relaxation. The nitrate drugs that are used for angina and also recreationally (poppers) are NO donors and are contraindicated with Viagra (sildenafil), Levitra (vardenafil) and Cialis (tadalafil) because the combination can lead to a serious decrease in blood pressure. These PDE-5 inhibitors work in conjunction with sexual stimulation by blocking PDE activity in cells, resulting in increased levels of NO and cGMP which assists an erection by smooth muscle relaxation of blood vessels causing inflow of blood into the corpus cavernosum.

They might be different molecules but they are part of a drug family (ending in ...fil) and the only pharmacological significance is the specificity of the blocking of degradation of cGMP activity at the PDE-5 receptor. Viagra is the least specific of the PDE-5 inhibitors as it also blocks activity at the PDE-6 receptor in the retina which is the reason for its visual disturbances side effects.

[subtle]

Originally Posted by Lady Anna

Mistresses usually advise no Viagra, no Cialis, or similar.

Although one fairly high profile Domme I've come across (so to speak) seems to enjoy administering suchlike things in combo with a chastity device

[EmpressMartine]

Originally Posted by subtle

Although one fairly high profile Domme I've come across (so to speak) seems to enjoy administering suchlike things in combo with a chastity device

You do need medical knowledge when administering vigra etc.I have heard of reports of bad reactions when this drug came into contact with amphetamines.

[slutsadie]

ive taken viagra for many years. i have too because of a spinal injury, that caused an errection problem
ive never had a problem taking poppers with it.
but then i do take the original ones from the nhs